Production, Processing, and Characterization of Synthetic AAV Gene Therapy Vectors
نویسندگان
چکیده
منابع مشابه
Engineering and evolution of synthetic adeno-associated virus (AAV) gene therapy vectors via DNA family shuffling.
Adeno-associated viral (AAV) vectors represent some of the most potent and promising vehicles for therapeutic human gene transfer due to a unique combination of beneficial properties(1). These include the apathogenicity of the underlying wildtype viruses and the highly advanced methodologies for production of high-titer, high-purity and clinical-grade recombinant vectors(2). A further particula...
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Adeno-associated virus (AAV) vectors have emerged as a safe and efficient gene therapy platform. One complication is that a significant amount of empty particles have always been generated as impurities during AAV vector production. However, the effects of such particles on AAV vector performance remain unclear. Here we systemically evaluated the biological properties of three types of "empty" ...
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ژورنال
عنوان ژورنال: Biotechnology Journal
سال: 2020
ISSN: 1860-6768,1860-7314
DOI: 10.1002/biot.202000025